Parkin Antibody (N-term) [APR32280G]

Product Specifications

Background

Tissue Location: Highly expressed in the brain including the substantia nigra (PubMed:9560156, PubMed:19501131) . Expressed in heart, testis and skeletal muscle (PubMed:9560156) . Expression is down- regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients (PubMed:14614460, PubMed:12719539) . Overexpression protects dopamine neurons from kainate-mediated apoptosis (PubMed:12628165) Found in serum (at protein level) (PubMed:19501131)

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Parkin Antibody (N-term) [APR32280G].

Synonyms

E3 ubiquitin-protein ligase parkin, 632-, Parkinson juvenile disease protein 2, Parkinson disease protein 2, PARK2, PRKN

Gene Name

HGNC:8607

Gene ID

5071

UniProt

O60260

Chromosomal Location

Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Mitochondrion. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9WVS6}. Cell projection, neuron projection. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q9WVS6}. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:Q9WVS6}. Note=Mainly localizes in the cytosol (PubMed:19029340, PubMed:19229105) . Co-localizes with SYT11 in neutrites (PubMed:12925569) . Co-localizes with SNCAIP in brainstem Lewy bodies (PubMed:10319893, PubMed:11431533) . Translocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1-dependent (PubMed:24898855, PubMed:18957282, PubMed:19966284, PubMed:23620051) Mitochondrial localization also gradually increases with cellular growth (PubMed:22082830) .

Applications

Dilution

WB--1:2000 FC--1:10~50 IF--1:10~50 IHC-P--1:100~500 WB--1:250-1:1000 WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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