MARCH5 Antibody (N-term) [APR32187G]
Product Specifications
Background
Tissue Location: Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MARCH5 Antibody (N-term) [APR32187G].
Synonyms
E3 ubiquitin-protein ligase MARCH5, 632-, Membrane-associated RING finger protein 5, Membrane-associated RING-CH protein V, MARCH-V, Mitochondrial ubiquitin ligase, MITOL, RING finger protein 153, MARCH5, RNF153
Gene Name
HGNC:26025
Gene ID
54708
UniProt
Q9NX47
Chromosomal Location
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266) . Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301)
Applications
IHC-P-Leica, WB
Dilution
IHC-P-Leica--1:500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Molecular Weight
31232
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=54708
Uniprot URL
https://www.uniprot.org/uniprot/Q9NX47
Available Sizes
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