CMPK2 Antibody (Center) [APR32135G]

Product Specifications

Background

Tissue Location: Among all investigated tumors, leukemia cells show the most abundant expression.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CMPK2 Antibody (Center) [APR32135G].

Synonyms

UMP-CMP kinase 2, mitochondrial, Nucleoside-diphosphate kinase, CMPK2

Gene Name

CMPK2

Gene ID

129607

UniProt

Q5EBM0

Chromosomal Location

Mitochondrion.

Applications

WB, IHC-P, FC

Dilution

WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.