ANO6 Antibody (N-term) [APR31932G]

Product Specifications

Background

Tissue Location: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ANO6 Antibody (N-term) [APR31932G].

Synonyms

Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, ANO6, TMEM16F

Gene Name

HGNC:25240

Gene ID

196527

UniProt

Q4KMQ2

Chromosomal Location

Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium- dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity) . Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.