ANO6 Antibody (N-term) [APR31932G]
Product Specifications
Background
Tissue Location: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer
Synonyms
Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, ANO6, TMEM16F
Gene Name
HGNC:25240
Gene ID
196527
UniProt
Q4KMQ2
Chromosomal Location
Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium- dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity) . Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Molecular Weight
106165
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ANO6 Antibody (N-term) [APR31932G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=196527
Uniprot URL
https://www.uniprot.org/uniprot/Q4KMQ2
Available Sizes
Curated Selection
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