BMPR2 Antibody (N-term) [APR31907G]
Product Specifications
Background
Tissue Location: Highly expressed in heart and liver.
Synonyms
Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1
Gene Name
BMPR2
Gene ID
659
UniProt
Q13873
Chromosomal Location
Cell membrane; Single-pass type I membrane protein
Applications
WB, IHC-P, FC
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Molecular Weight
115201
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BMPR2 Antibody (N-term) [APR31907G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=659
Uniprot URL
https://www.uniprot.org/uniprot/Q13873
Available Sizes
Curated Selection
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