POLK Antibody (Center) [APR31899G]
Product Specifications
Background
Tissue Location: Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes
Synonyms
DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
Gene Name
POLK
Gene ID
51426
UniProt
Q9UBT6
Chromosomal Location
Nucleus. Note=Detected throughout the nucleus and at replication foci (PubMed:12414988) . Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A) - containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK (PubMed:28297716)
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Molecular Weight
98809
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality POLK Antibody (Center) [APR31899G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=51426
Uniprot URL
https://www.uniprot.org/uniprot/Q9UBT6
Available Sizes
Curated Selection
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