Mouse Cbx5 Antibody (C-term) [APR31797G]
Product Specifications
Synonyms
Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, HP1 alpha, Cbx5, Hp1a
Gene Name
Cbx5
Gene ID
12419
UniProt
Q61686
Chromosomal Location
Nucleus {ECO:0000250|UniProtKB:P45973}. Chromosome. Chromosome, centromere. Note=Colocalizes with HNRNPU in the nucleus (By similarity) . Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase {ECO:0000250|UniProtKB:P45973}
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity) .
Molecular Weight
22186
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Cbx5 Antibody (C-term) [APR31797G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=12419
Uniprot URL
https://www.uniprot.org/uniprot/Q61686
Available Sizes
Curated Selection
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