GATSL1 Antibody (N-term) [APR31776G]
Product Specifications
Background
Tissue Location: Widely expressed..
Synonyms
GATS-like protein 1, GATSL1
Gene Name
CASTOR2 {ECO:0000303|PubMed:26972053, ECO:0000312|HGNC:HGNC:37073}
Gene ID
729438
UniProt
A6NHX0
Chromosomal Location
Cytoplasm, cytosol.
Applications
IHC-P-Leica, WB
Dilution
IHC-P-Leica--1:250 WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2- containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Molecular Weight
36056
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GATSL1 Antibody (N-term) [APR31776G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=729438
Uniprot URL
https://www.uniprot.org/uniprot/A6NHX0
Available Sizes
Curated Selection
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