GATSL1 Antibody (N-term) [APR31776G]

Product Specifications

Background

Tissue Location: Widely expressed..

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GATSL1 Antibody (N-term) [APR31776G].

Synonyms

GATS-like protein 1, GATSL1

Gene Name

CASTOR2 {ECO:0000303|PubMed:26972053, ECO:0000312|HGNC:HGNC:37073}

Gene ID

729438

UniProt

A6NHX0

Chromosomal Location

Cytoplasm, cytosol.

Applications

IHC-P-Leica, WB

Dilution

IHC-P-Leica--1:250 WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2- containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.