THOC3 Antibody (N-term) [APR31595G]
Product Specifications
Synonyms
THO complex subunit 3, Tho3, TEX1 homolog, hTREX45, THOC3
Gene Name
THOC3
Gene ID
84321
UniProt
Q96J01
Chromosomal Location
Nucleus. Nucleus speckle
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Molecular Weight
38772
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality THOC3 Antibody (N-term) [APR31595G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=84321
Uniprot URL
https://www.uniprot.org/uniprot/Q96J01
Available Sizes
Curated Selection
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