IMPACT Antibody (N-term) [APR31556G]
Product Specifications
Background
Tissue Location: Widely expressed. Expressed at high level in brain.
Synonyms
Protein IMPACT, Imprinted and ancient gene protein homolog, IMPACT
Gene Name
IMPACT
Gene ID
55364
UniProt
Q9P2X3
Chromosomal Location
Cytoplasm {ECO:0000250|UniProtKB:O55091}.
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Molecular Weight
36476
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IMPACT Antibody (N-term) [APR31556G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=55364
Uniprot URL
https://www.uniprot.org/uniprot/Q9P2X3
Available Sizes
Curated Selection
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