CIR Antibody (C-term) [APR31211G]

Product Specifications

Background

Tissue Location: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CIR Antibody (C-term) [APR31211G].

Synonyms

Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin, CIR1, CIR

Gene Name

CIR1

Gene ID

9541

UniProt

Q86X95

Chromosomal Location

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity) . Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC) . Required for RBPJ-mediated repression of transcription.