NOX4 Antibody (N-term) [APR31190G]
Product Specifications
Background
Tissue Location: Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level) . Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells
Synonyms
NADPH oxidase 4, 163-, Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD (P) H-oxidase, NOX4, RENOX
Gene Name
NOX4
Gene ID
50507
UniProt
Q9NPH5
Chromosomal Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell junction, focal adhesion Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus
Applications
IHC-P, WB
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.
Molecular Weight
66932
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NOX4 Antibody (N-term) [APR31190G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=50507
Uniprot URL
https://www.uniprot.org/uniprot/Q9NPH5
Available Sizes
Curated Selection
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