H2AFX Antibody (C-term) [APR31151G]
Product Specifications
Synonyms
Histone H2AX, H2a/x, Histone H2AX, H2AFX, H2AX
Gene Name
HGNC:4739
Gene ID
3014
UniProt
P16104
Chromosomal Location
Nucleus. Chromosome
Applications
WB, IHC-P
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Molecular Weight
15145
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality H2AFX Antibody (C-term) [APR31151G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3014
Uniprot URL
https://www.uniprot.org/uniprot/P16104
Available Sizes
Curated Selection
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