PPARA Antibody (Center) [APR31038G]
Product Specifications
Background
Tissue Location: Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758) .
Synonyms
Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR
Gene Name
PPARA
Gene ID
5465
UniProt
Q07869
Chromosomal Location
Nucleus.
Applications
WB, FC
Dilution
WB--1:1000 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Molecular Weight
52225
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PPARA Antibody (Center) [APR31038G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5465
Uniprot URL
https://www.uniprot.org/uniprot/Q07869
Available Sizes
Curated Selection
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