What is the catalog number for PIASy Antibody (N-term) [APR30965G]?

The catalog number for PIASy Antibody (N-term) [APR30965G] is APR30965G.

What sizes are available for PIASy Antibody (N-term) [APR30965G]?

PIASy Antibody (N-term) [APR30965G] is available in the following size(s): 50 µL, 100 µL, 200 µL, 400 µL.

How many pack sizes does PIASy Antibody (N-term) [APR30965G] come in?

PIASy Antibody (N-term) [APR30965G] is available in 4 different pack sizes.

Is PIASy Antibody (N-term) [APR30965G] in stock?

PIASy Antibody (N-term) [APR30965G] is currently made to order / not held in immediate stock. Contact us for lead time.

PIASy Antibody (N-term) [APR30965G]

Product Specifications

Background

Tissue Location: Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PIASy Antibody (N-term) [APR30965G].

Synonyms

E3 SUMO-protein ligase PIAS4, 632-, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma, PIAS-gamma, PIAS4, PIASG

Gene Name

PIAS4

Gene ID

51588

UniProt

Q8N2W9

Chromosomal Location

Nucleus, PML body Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies

Applications

WB, IHC-P

Dilution

WB--1:1000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.