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SOX15 Antibody (Center) [APR30960G]

Product Specifications

Background

Tissue Location: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SOX15 Antibody (Center) [APR30960G].

Synonyms

Protein SOX-15, Protein SOX-12, Protein SOX-20, SOX15, SOX12, SOX20, SOX26, SOX27

Gene Name

SOX15

Gene ID

6665

UniProt

O60248

Chromosomal Location

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.

Applications

IHC-P, WB

Dilution

WB--1:1000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity) . Acts as a transcriptional activator and repressor (By similarity) . Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity) . Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity) . Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity) . Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity) . Regulates transcription of HRC via binding to it proximal enhancer region (By similarity) . Involved in skeletal muscle regeneration (By similarity) . Also plays a role in the development of myogenic precursor cells (By similarity) .

Molecular Weight

25251

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=6665

Uniprot URL

https://www.uniprot.org/uniprot/O60248

Available Sizes

Frequently Asked Questions

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