SENP3 Antibody (N-term) [APR30934G]

Product Specifications

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SENP3 Antibody (N-term) [APR30934G].

Synonyms

Sentrin-specific protease 3, SUMO-1-specific protease 3, Sentrin/SUMO-specific protease SENP3, SENP3, SSP3, SUSP3

Gene Name

SENP3

Gene ID

26168

UniProt

Q9H4L4

Chromosomal Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm {ECO:0000250|UniProtKB:Q9EP97} Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224) . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity) . {ECO:0000250|UniProtKB:Q9EP97, ECO:0000269|PubMed:19680224}

Applications

WB, IHC-P

Dilution

WB--1:1000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.