PRDM14 Antibody (N-term) [APR30906G]
Product Specifications
Background
Tissue Location: Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level)
Synonyms
PR domain zinc finger protein 14, 211-, PR domain-containing protein 14, PRDM14
Gene Name
PRDM14
Gene ID
63978
UniProt
Q9GZV8
Chromosomal Location
Nucleus.
Applications
WB, IHC-P, IF
Dilution
WB--1:1000 IHC-P--1:100~500 IF--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity) . Directly up- regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA- 3'.
Molecular Weight
64062
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PRDM14 Antibody (N-term) [APR30906G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=63978
Uniprot URL
https://www.uniprot.org/uniprot/Q9GZV8
Available Sizes
Curated Selection
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