TBX6 Antibody (Center) [APR30891G]

Product Specifications

Background

Tissue Location: Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TBX6 Antibody (Center) [APR30891G].

Synonyms

T-box transcription factor TBX6, T-box protein 6, TBX6

Gene Name

TBX6

Gene ID

6911

UniProt

O95947

Chromosomal Location

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.

Applications

IF, WB

Dilution

IF--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity) .