PURB Antibody (C-term) [APR30888G]

Product Specifications

Background

Tissue Location: Expressed in myocardium of heart failure patients.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PURB Antibody (C-term) [APR30888G].

Synonyms

Transcriptional activator protein Pur-beta, Purine-rich element-binding protein B, PURB

Gene Name

PURB

Gene ID

5814

UniProt

Q96QR8

Chromosomal Location

Nucleus.

Applications

WB, IF, FC

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity) .