COL8A2 Antibody (C-term) [APR30857G]
Product Specifications
Background
Tissue Location: Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane
Synonyms
Collagen alpha-2 (VIII) chain, Endothelial collagen, COL8A2
Gene Name
COL8A2
Gene ID
1296
UniProt
P25067
Chromosomal Location
Secreted, extracellular space, extracellular matrix, basement membrane
Applications
IHC-P-Leica, IF, WB
Dilution
IHC-P-Leica--1:500 WB--1:2000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) .
Molecular Weight
67244
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COL8A2 Antibody (C-term) [APR30857G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1296
Uniprot URL
https://www.uniprot.org/uniprot/P25067
Available Sizes
Curated Selection
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