TMEM66 Antibody (N-term) [APR30672G]
Product Specifications
Background
Tissue Location: Highly expressed in macrophages. {ECO:0000269|Ref.2}
Synonyms
Store-operated calcium entry-associated regulatory factor, SARAF, SOCE-associated regulatory factor, HBV X-transactivated gene 3 protein, HBV XAg-transactivated protein 3, Protein FOAP-7, Transmembrane protein 66, SARAF, TMEM66, XTP3
Gene Name
SARAF
Gene ID
51669
UniProt
Q96BY9
Chromosomal Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca (2+) elevation
Applications
WB, FC
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Negative regulator of store-operated Ca (2+) entry (SOCE) involved in protecting cells from Ca (2+) overfilling. In response to cytosolic Ca (2+) elevation after endoplasmic reticulum Ca (2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2) - dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca (2+) levels, and thus preventing the overload of the cell with excessive Ca (2+) ions.
Molecular Weight
36975
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TMEM66 Antibody (N-term) [APR30672G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=51669
Uniprot URL
https://www.uniprot.org/uniprot/Q96BY9
Available Sizes
Curated Selection
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