HP Antibody (Center) [APR30660G]

Product Specifications

Background

Tissue Location: Expressed by the liver and secreted in plasma.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HP Antibody (Center) [APR30660G].

Synonyms

Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP

Gene Name

Gene ID

3240

UniProt

P00738

Chromosomal Location

Secreted.

Applications

IHC-P-Leica, FC, IF, WB

Dilution

IHC-P-Leica--1:500 WB--1:2000 WB--1:1000 WB--1:1000-1:2000 IHC-P--1:100~500 FC--1:10~50 IF--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.