C12orf48 Antibody (C-term) [APR30544G]

Product Specifications

Background

Tissue Location: Restricted to testis. Overexpressed in multiple cancer cells.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality C12orf48 Antibody (C-term) [APR30544G].

Synonyms

PCNA-interacting partner, PARI, PARP-1 binding protein, PARP1-binding protein, PARPBP, PARPBP, C12orf48, PARI

Gene Name

PARPBP

Gene ID

55010

UniProt

Q9NWS1

Chromosomal Location

Cytoplasm. Nucleus Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA

Applications

WB, IHC-P, FC

Dilution

WB--1:1000 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly (A) homopolymers. Positively regulate the poly (ADP-ribosyl) ation activity of PARP1; however such function may be indirect.