Drosophila Parkin Antibody (N-term) [APR30491G]
Product Specifications
Background
Tissue Location: In oocytes, accumulates in early egg chambers where it is enriched until stages 9-10, localizing mainly to the posterior pole and anterior margin (at protein level) (PubMed:20869429) . After stage 10 it is no longer detected in the oocyte (at protein level) (PubMed:20869429) . In embryos, ubiquitously expressed in the early stages (stages 2 to 5) (at protein level) (PubMed:14646593) . Expression levels decrease at later stages and becomes restricted to the brain and nerve cord from stage 9 (at protein level) (PubMed:14646593) Relatively higher levels of expression in the head compared to the body (PubMed:16002472) . Enriched in the dorsomedial (DM) dopaminergic neurons (PubMed:16002472) .
Synonyms
CG10523-PB; isoform B; Cg10523-pc; isoform c; PARKIN; park; parkin
Gene Name
Park {ECO:0000303|PubMed:17123504, ECO:0000312|FlyBase:FBgn0041100}
Gene ID
40336
UniProt
Q7KTX7
Chromosomal Location
Mitochondrion. Cytoplasm, cytosol Note=Translocates from the cytosol to dysfunctional mitochondria that have lost their mitochondrial membrane potential; recruitment to mitochondria is Pink1-dependent.
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
160024721745643825474007201947542419265324901221279061793171492932138754320470332377091718957282249012212547400723650379279061793171492932047033126426581507315216672980166729811712350418957282187997311823072318443288204961232019475423509287241926532490122125474007279061792949736432047033126426581507315216002472166729801667298117123504189572821879973118230723184432882049612320194754235092872419265324901221254740072790617929497364320470331264265815073152160024721667298017123504187997312048337222396657249012212843510429497364317149291895728224901221201947542239665718799731182307232547400727906179320470331667298016672981201947541895728223509287241926532547400729497364320470332365037916002472204961231844328817123504187997311823072320194754236503792419265324901221294973641844328817123504187997311823072320194754236503792419265324901221294973642239665716672980204961232086942923509287236503792419265325565208294973642350928729497364321387542350928725565208
Molecular Weight
54105
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Drosophila Parkin Antibody (N-term) [APR30491G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=40336
Uniprot URL
https://www.uniprot.org/uniprot/Q7KTX7
Available Sizes
Curated Selection
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