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Drosophila Parkin Antibody (N-term) [APR30491G]

Product Specifications

Background

Tissue Location: In oocytes, accumulates in early egg chambers where it is enriched until stages 9-10, localizing mainly to the posterior pole and anterior margin (at protein level) (PubMed:20869429) . After stage 10 it is no longer detected in the oocyte (at protein level) (PubMed:20869429) . In embryos, ubiquitously expressed in the early stages (stages 2 to 5) (at protein level) (PubMed:14646593) . Expression levels decrease at later stages and becomes restricted to the brain and nerve cord from stage 9 (at protein level) (PubMed:14646593) Relatively higher levels of expression in the head compared to the body (PubMed:16002472) . Enriched in the dorsomedial (DM) dopaminergic neurons (PubMed:16002472) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Drosophila Parkin Antibody (N-term) [APR30491G].

Synonyms

CG10523-PB; isoform B; Cg10523-pc; isoform c; PARKIN; park; parkin

Gene Name

Park {ECO:0000303|PubMed:17123504, ECO:0000312|FlyBase:FBgn0041100}

Gene ID

40336

UniProt

Q7KTX7

Chromosomal Location

Mitochondrion. Cytoplasm, cytosol Note=Translocates from the cytosol to dysfunctional mitochondria that have lost their mitochondrial membrane potential; recruitment to mitochondria is Pink1-dependent.

Applications

WB

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

160024721745643825474007201947542419265324901221279061793171492932138754320470332377091718957282249012212547400723650379279061793171492932047033126426581507315216672980166729811712350418957282187997311823072318443288204961232019475423509287241926532490122125474007279061792949736432047033126426581507315216002472166729801667298117123504189572821879973118230723184432882049612320194754235092872419265324901221254740072790617929497364320470331264265815073152160024721667298017123504187997312048337222396657249012212843510429497364317149291895728224901221201947542239665718799731182307232547400727906179320470331667298016672981201947541895728223509287241926532547400729497364320470332365037916002472204961231844328817123504187997311823072320194754236503792419265324901221294973641844328817123504187997311823072320194754236503792419265324901221294973642239665716672980204961232086942923509287236503792419265325565208294973642350928729497364321387542350928725565208

Molecular Weight

54105

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=40336

Uniprot URL

https://www.uniprot.org/uniprot/Q7KTX7

Available Sizes

Frequently Asked Questions

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