ADAMTS4 Antibody [AMM22274G]
Product Specifications
Background
Tissue Location: Expressed in brain, lung and heart (PubMed:23897278) . Expressed at very low level in placenta and skeletal muscles (PubMed:23897278) . Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)
Synonyms
A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688
Gene Name
ADAMTS4
Gene ID
9507
UniProt
O75173
Chromosomal Location
Secreted, extracellular space, extracellular matrix
Applications
WB
Dilution
WB--1:8000
Function
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Molecular Weight
90197
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ADAMTS4 Antibody [AMM22274G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=9507
Uniprot URL
https://www.uniprot.org/uniprot/O75173
Available Sizes
Curated Selection
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