ADAMTS4 Antibody [AMM22274G]

Product Specifications

Background

Tissue Location: Expressed in brain, lung and heart (PubMed:23897278) . Expressed at very low level in placenta and skeletal muscles (PubMed:23897278) . Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ADAMTS4 Antibody [AMM22274G].

Synonyms

A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688

Gene Name

ADAMTS4

Gene ID

9507

UniProt

O75173

Chromosomal Location

Secreted, extracellular space, extracellular matrix

Applications

Dilution

WB--1:8000

Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Molecular Weight

90197

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.