XRN1 Antibody [AMM22202G]
Product Specifications
Background
Tissue Location: Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality XRN1 Antibody [AMM22202G].
Synonyms
5'-3' exoribonuclease 1, 3.1.13.-, Strand-exchange protein 1 homolog, XRN1, SEP1
Gene Name
XRN1
Gene ID
54464
UniProt
Q8IZH2
Chromosomal Location
Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane
Applications
WB
Dilution
WB--1:2000
Function
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity) . Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) .
Molecular Weight
194107
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=54464
Uniprot URL
https://www.uniprot.org/uniprot/Q8IZH2
Available Sizes
Frequently Asked Questions
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