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NKG2D Protein, Rhesus, Recombinant (aa 78-216, His Tag)

Product Specifications

Background

KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. To transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.

Synonyms

KLRK1 Protein, Rhesus; NKG2-D Protein, Rhesus; NKG2D Protein, Rhesus

Gene Name

Killer cell lectin-like receptor subfamily K, member 1

Expression System

Baculovirus-Insect Cells

Tag

N-His

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by SDS-PAGE.

Activity

1. Immobilized Rhesus His-NKG2D (78-216) at 10 μg/ml (100 μl/well) can bind human ULBP1-Fch (Cat:PH50911M4), The ECof human ULBP1-Fch (Cat:PH50911M4) is 0.12-0.28 μg/ml. 2. Immobilized Rhesus His-NKG2D (78-216) at 10 μg/ml (100 μl/well) can bind human MICB-Fch (Cat:10759-H03H), The ECof human MICB-Fch (Cat:10759-H03H) is 33.8-79 ng/ml.

Form

Lyophilized

Buffer

Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Function

CD Molecule proteins, Immune Checkpoint Proteins, Biological Target proteins

Molecular Weight

The recombinant rhesus NKG2D consists of 155 amino acids and has a calculated molecular mass of 18.3 kDa.

Storage Conditions

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Product Datasheet

http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PK53979I1.pdf

Symbol

KLRK1

Species

Rhesus

Protein ID

NP_001028061.1

Overview

A DNA sequence encoding the rhesus NKG2D (NP_001028061.1) (Phe78-Val216) was expressed with a polyhistide tag at the N-terminus.

AA Sequence

Phe78-Val216

Protein ID Link

https://www.ncbi.nlm.nih.gov/protein/NP_001028061.1

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