Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

BTLA Protein, Rat, Recombinant (ECD, mFc Tag)

Product Specifications

Background

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism (s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T (H) 1) but not T (H) 2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) .

Gene Name

B and T lymphocyte associated

Expression System

HEK293 Cells

Tag

C-mFc

Field of Research

Cancer Drug Targets ITIM/ITAM Immunoreceptors and Related Molecules

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

> 90 % as determined by SDS-PAGE.

Activity

1. Measured by its binding ability in a functional ELISA. 2. Immobilized rat BTLA-mFc at 10 μg/mL (100 μL/well) can bind mouse HVEM-Fch (Cat:10567-M03S) . The ECof mouse EFNA5-Fc (Cat:PM53390M4) is 6.2-14.4 ng/mL.

Form

Lyophilized

Buffer

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Function

Immune Checkpoint Proteins, Biological Target proteins, B7 Family proteins, CD Molecule proteins, Cancer proteins, Immunotherapy proteins

Molecular Weight

The recombinant rat Btla consists 384 amino acids and predicts a molecular mass of 43.4 kDa.

Storage Conditions

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Product Datasheet

http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PR53882M4.pdf

Symbol

BTLA

Species

Rat

Protein ID

NP_998795.1

Overview

A DNA sequence encoding the rat Btla (NP_998795.1) (Ala6-Tyr183) was expressed with the Fc region of mouse IgG1 at the C-terminus.

AA Sequence

Ala6-Tyr183

Protein ID Link

https://www.ncbi.nlm.nih.gov/protein/NP_998795.1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

HG6-64-1
BA6533-100 100 mg

HG6-64-1

Ask
View Details
Erg (NM_133659) Mouse Tagged ORF Clone Lentiviral Particle
MR225536L4V 200 µL

Erg (NM_133659) Mouse Tagged ORF Clone Lentiviral Particle

Ask
View Details
TLK1 Recombinant Protein Antigen
NBP1-83035PEP 0.1 mL

TLK1 Recombinant Protein Antigen

Ask
View Details
Ox40 (2Q1716) FITC
sc-71768 FITC 200 µg/mL

Ox40 (2Q1716) FITC

Ask
View Details
GRL-104
021-91 200 μg

GRL-104

Ask
View Details