CD40 Protein, Mouse, Recombinant (ECD, His Tag)

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3) . In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

AI326936 Protein, Mouse; Bp50 Protein, Mouse; GP39 Protein, Mouse; HIGM1 Protein, Mouse; IGM Protein, Mouse; IMD3 Protein, Mouse; p50 Protein, Mouse; T-BAM Protein, Mouse; Tnfrsf5 Protein, Mouse; TRAP Protein, Mouse

Measured by its binding ability in a functional ELISA. Immobilized CD40 Protein, Mouse, (ECD, His Tag) (PM53472M2) at 2 μg/mL (100 μL/well) can bind CD40 Ligand Protein, Human, (hFc Tag) (PH52245M3), the ECof CD40 L-hFc is 70-180 ng/mL.

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

CD Molecule proteins, Immune Checkpoint Proteins, epigenetic proteins, Receptor Proteins, Cancer proteins, Biological Target proteins, Immunotherapy proteins

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.