CD155/PVR Protein, Mouse, Recombinant (ECD, hFc & AVI Tag), Biotinylated

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

3830421F03Rik Protein, Mouse; CD155 Protein, Mouse; D7Ertd458e Protein, Mouse; HVED Protein, Mouse; mE4 Protein, Mouse; necl-5 Protein, Mouse; PVS Protein, Mouse; Taa1 Protein, Mouse; Tage4 Protein, Mouse

1. Measured by its binding ability in a functional ELISA. Immobilized Mouse CD226-Fch (Cat:50232-M03H) at 10 μg/mL (100 μL/well) can bind mPVR-Fc-Avi (Cat:PM52829M4), the ECof mPVR-Fc-Avi (Cat:PM52829M4) is 15-45 ng/mL. 2. Measured by its ability to bind NECTIN4/Nectin 4 Protein, Human, Recombinant (ECD, His Tag) (Cat:PH51950M2) in functional Elisa.

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

A DNA sequence encoding the human PVR (NP_081790.1) (Met1-Arg345) was expressed with a c-terminal Fc region of human IgG1 tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.