H Cadherin Protein, Mouse, Recombinant (hFc Tag)
Product Specifications
Background
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer.
Synonyms
4932416G01Rik Protein, Mouse; Cdht Protein, Mouse; T-cadherin Protein, Mouse; Tcad Protein, Mouse
Gene Name
Cadherin 13
Expression System
HEK293 Cells
Tag
C-hFc
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 80 % as determined by SDS-PAGE.
Activity
At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.
Form
Lyophilized
Buffer
Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Biomarker Proteins, Diagnostic proteins
Molecular Weight
The recombinant mouse Cdh13 consists 911 amino acids and predicts a molecular mass of 100.6 kDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PM52753M4.pdf
Symbol
CDH13
Species
Mouse
Protein ID
NP_062681.2
Overview
A DNA sequence encoding the mouse Cdh13 (NP_062681.2) (Met1-Ala692) was expressed with the Fc region of human IgG1 at the C-terminus.
AA Sequence
Met1-Ala692
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_062681.2
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