Bim Protein, Human, Recombinant (His Tag)
Product Specifications
Background
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3) . It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X (L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Synonyms
BAM Protein, Human; BIM Protein, Human; BOD Protein, Human
Gene Name
BCL2-like 11 (apoptosis facilitator)
Expression System
E. coli
Tag
N-His
Endotoxin
Please contact us for more information.
Purity
> 90 % as determined by SDS-PAGE.
Activity
At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.
Form
Lyophilized
Buffer
Lyophilized from sterile 50mM Tris, 10% Glycerol, pH 8.0. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Molecular Weight
The recombinant human BCL2L11 consists of 130 amino acids and predicts a molecular mass of 15 KDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH52353E1.pdf
Symbol
BCL2L11
Species
Human
Protein ID
NP_006529.1
Overview
A DNA sequence encoding the human BCL2L11 (NP_006529.1) (Ala2-Arg120) was expressed with a polyhistide tag at the N-terminus.
AA Sequence
Ala2-Arg120
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_006529.1
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