BMS 299897

BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP) .

Product Specifications

CAS Number

[290315-45-6]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BMS-299897.html

Purity

99.64

Solubility

DMSO : ≥ 30 mg/mL

Smiles

FC1=CC=C(F)C(N([C@@H](C2=C(CCCC(O)=O)C=C(F)C=C2)C)S(C3=CC=C(Cl)C=C3)(=O)=O)=C1

Molecular Formula

C24H21ClF3NO4S

Molecular Weight

511.94

Precautions

H302, H319

References & Citations

[1]Meunier J, et al. The γ-secretase inhibitor 2-[ (1R) -1-[ (4-chlorophenyl) sulfonyl] (2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's d|[2]Weissmiller AM, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10 (2) :e0118379.