MST1 Protein, Human, Recombinant (His Tag)
Product Specifications
Background
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC) . STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.
Synonyms
KRS2 Protein, Human; MST1 Protein, Human; TIIAC Protein, Human; YSK3 Protein, Human
Gene Name
Serine/threonine kinase 4
UniProt
Q13043-1
Expression System
Baculovirus-Insect Cells
Tag
N-His
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 92 % as determined by SDS-PAGE.
Activity
The specific activity was determined to be > 150 nmol/min/mg using MBP as substrate.
Form
Liquid
Buffer
Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Function
Enzyme Proteins
Molecular Weight
The recombinant human STK4 consists of 505 amino acids and migrates as an approximately 58 kDa band in SDS-PAGE under reducing conditions as predicted.
Storage Conditions
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH52315I1.pdf
Symbol
STK4
Species
Human
Overview
A DNA sequence encoding the human STK4 isoform 1 (Q13043-1) (Glu 2-Phe 487) was expressed, with a polyhistidine tag at the N-terminus.
Uniprot URL
https://www.uniprot.org/uniprot/Q13043-1
AA Sequence
Glu2-Phe487
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