ADAM8/CD156a Protein, Human, Recombinant (ECD, His Tag)
Product Specifications
Background
ADAM8, also known as CD156, is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM8 is possiblely involved in extravasation of leukocytes As a metalloprotease, ADAM8 also may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.
Synonyms
CD156 Protein, Human; CD156a Protein, Human; MS2 Protein, Human
Gene Name
ADAM metallopeptidase domain 8
Expression System
HEK293 Cells
Tag
C-His
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE.
Activity
At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.
Form
Lyophilized
Buffer
Lyophilized from sterile 12.5 mM Tris, 5 mM CaCl2, 75 mM NaCl, 50% glycerol, pH 7.5. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
CD Molecule proteins, Protease proteins, Enzyme Proteins
Molecular Weight
The recombinant human ADAM8 consists of 648 amino acids and predicts a molecular mass of 71 kDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH52287M2.pdf
Symbol
ADAM8
Species
Human
Protein ID
AAI15405.1
Overview
A DNA sequence encoding the human ADAM8 (AAI15405.1) (Met1-Ser653) was expressed with a polyhistidine tag at the C-terminus.
AA Sequence
Met1-Ser653
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/AAI15405.1
Available Sizes
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