EpCAM Protein, Human, Recombinant (ECD, His & AVI Tag), Biotinylated

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type a…transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

DIAR5 Protein, Human; EGP-2 Protein, Human; EGP314 Protein, Human; EGP40 Protein, Human; ESA Protein, Human; HNPCC8 Protein, Human; KS1/4 Protein, Human; KSA Protein, Human; M4S1 Protein, Human; MIC18 Protein, Human; MK-1 Protein, Human; TACSTD1 Protein, Human; TROP-1 Protein, Human; TROP1 Protein, Human

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

CD Molecule proteins, Diagnostic proteins, CAR T Cell Therapy Target Proteins, Biomarker Proteins, Biological Target proteins, Immunotherapy proteins, Biotinylated proteins, Cancer proteins

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

A DNA sequence encoding the human EPCAM (NP_002345.2) (Met1-Lys265) was expressed with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.