LPAL2 Protein, Human, Recombinant (mFc Tag)

LPAL2 (Lipoprotein (A) Like 2, Pseudogene) is a Pseudogene. This gene is similar to the lipoprotein, Lp (a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Lipoprotein (a) [Lp (a) ] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD) . Mutations in the solute carrier family 22 member 3 (SLC22A3), lipoprotein (a) -like 2 (LPAL2), and the lipoprotein (a) (LPA) gene cluster, which encodes apolipoprotein (a) [apo (a) ] of the lipoprotein (a) [Lp (a) ] lipoprotein particle, have been suggested to contribute to the risk of coronary artery disease (CAD) . Recent genome-wide association studies have identified that genetic variants in the SLC22A3-LPAL2-LPA gene cluster influence plasma lipoprotein (a) [Lp (a) ] concentration.

At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

The recombinant human LPAL2/mFc comprises 345 amino acids and has a predicted molecular mass of 38.9 kDa. The apparent molecular mass of the protein is approximately 48.2 and 42.7 kDa in SDS-PAGE under reducing conditions.

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.