FGF17 Protein, Human, Recombinant

Product Specifications

Background

FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-13 is preferentially expressed in the embryonic brain. It interacts with FGFR3 and FGFR4. FGF-13 plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. It is also required for normal brain development.

Overview

A DNA sequence encoding the mature form of human FGF17 (O60258-1) (Thr23-Thr216) was expressed, with a N-terminal Met.

Synonyms

FGF-13 Protein, Human; FGF-17 Protein, Human; HH20 Protein, Human

Gene Name

Fibroblast growth factor 17

UniProt

O60258-1

Expression System

E. coli

Tag

No tag

Endotoxin

Please contact us for more information.

Purity

> 95 % as determined by SDS-PAGE.

Activity

Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts.The EDfor this effect is typically 0.6-3 μg/mL.

Form

Lyophilized

Buffer

Lyophilized from sterile 50mM Tris, 1M NaCl, PH 8.5 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Function

Cytokine Proteins, Biological Target proteins, Growth Factor proteins

Molecular Weight

The recombinant human FGF17 consists of 195 amino acids and predicts a molecular mass of 22.6 KDa. It migrates as an approximately 21 and 23 KDa band in SDS-PAGE under reducing conditions.

Storage Conditions

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.