BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc Tag)

Product Specifications

Background

BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.

Overview

A DNA sequence encoding the mature form of human / mouse / rat / rhesus / canine BMP2 (NP_001191.1) (Gln 283-Arg 396) was fused with the Fc region of human IgG1 at the N-terminus. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.

Gene Name

Bone morphogenetic protein 2

Expression System

HEK293 Cells

Tag

N-hFc

Field of Research

Early Mesodermal Lineage Markers

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by SDS-PAGE.

Activity

Measured by its ability to bind recombinant human BMPR-II-Fc (Cat:PH52301M4) in a functional ELISA.

Form

Lyophilized

Buffer

Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Function

Cytokine Proteins, Growth Factor proteins, Protease proteins, Biological Target proteins, TGF beta Family proteins, Cell Therapy proteins, Enzyme Proteins

Molecular Weight

The recombinant human / mouse / rat / rhesus / canine BMP2 consists of 351 amino acids and has a predicted molecular mass of 39.5 kDa.

Storage Conditions

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.