BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc Tag)
Product Specifications
Background
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.
Gene Name
Bone morphogenetic protein 2
Expression System
HEK293 Cells
Tag
N-hFc
Field of Research
Early Mesodermal Lineage Markers
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE.
Activity
Measured by its ability to bind recombinant human BMPR-II-Fc (Cat:PH52301M4) in a functional ELISA.
Form
Lyophilized
Buffer
Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Cytokine Proteins, Growth Factor proteins, Protease proteins, Biological Target proteins, TGF beta Family proteins, Cell Therapy proteins, Enzyme Proteins
Molecular Weight
The recombinant human / mouse / rat / rhesus / canine BMP2 consists of 351 amino acids and has a predicted molecular mass of 39.5 kDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH51094M3.pdf
Symbol
BMP2
Species
Human, Mouse, Rat, Rhesus, Canine
Protein ID
NP_001191.1
Overview
A DNA sequence encoding the mature form of human / mouse / rat / rhesus / canine BMP2 (NP_001191.1) (Gln 283-Arg 396) was fused with the Fc region of human IgG1 at the N-terminus. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.
AA Sequence
Gln283-Arg396
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_001191.1
Available Sizes
Curated Selection
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