PTPN9 Protein, Human, Recombinant (His & GST Tag)
Product Specifications
Background
Protein tyrosine phosphatase non-receptor type 9 (PTPN9), also named PTP-MEG2, is an important member of the protein tyrosine phosphatase family that is involved in variety of human diseases.PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89, providing new cellular and molecular insights into the role of ptpn9a in developmental hematopoiesis.
Synonyms
MEG2 Protein, Human; PTPMEG2 Protein, Human
Gene Name
Protein tyrosine phosphatase, non-receptor type 9
Expression System
Baculovirus-Insect Cells
Tag
N-GST & His
Field of Research
Phosphatases and Regulators
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 90 % as determined by SDS-PAGE.
Activity
At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.
Form
Lyophilized
Buffer
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Enzyme Proteins
Molecular Weight
The recombinant human PTPN9 consists 546 amino acids and predicts a molecular mass of 63.3 kDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH50935I6.pdf
Symbol
PTPN9
Species
Human
Protein ID
NP_002824.1
Overview
A DNA sequence encoding the human PTPN9 (NP_002824.1) (Ala285-Gln593) was expressed with a C-terminal polyhistidine-tagged GST tag at the N-terminus (his-GST) .
AA Sequence
Ala285-Gln593
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_002824.1
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