Fmoc-His (3-Me) -OH
Fmoc-His (3-Me) OH derives Histidine-associating compounds with biological activity. Fmoc-His (3-Me) OH, with Fmoc-citrulline-OH, Fmoc-His (1-Me) -OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE) -contracted aorta rings. Fmoc-His (3-Me) OH (resin) also makes Methyl-His-Gly-Lys (His (3-Me) -Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His (3-Me) OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel[1][2][3].
Product Specifications
CAS Number
252049-16-4
UNSPSC
12352209
Hazard Statement
H302, H312, H332
Target
Amino Acid Derivatives; Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fmoc-his-3-me-oh.html
Purity
99.91
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)[C@H](CC1=CN=CN1C)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O
Molecular Formula
C22H21N3O4
Molecular Weight
391.42
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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