Fmoc-His (3-Me) -OH

Fmoc-His (3-Me) OH derives Histidine-associating compounds with biological activity. Fmoc-His (3-Me) OH, with Fmoc-citrulline-OH, Fmoc-His (1-Me) -OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE) -contracted aorta rings. Fmoc-His (3-Me) OH (resin) also makes Methyl-His-Gly-Lys (His (3-Me) -Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His (3-Me) OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel[1][2][3].

Product Specifications

CAS Number

[252049-16-4]

UNSPSC

12352209

Hazard Statement

H302, H312, H332

Target

Amino Acid Derivatives; Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fmoc-his-3-me-oh.html

Purity

99.91

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)[C@H](CC1=CN=CN1C)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Molecular Formula

C22H21N3O4

Molecular Weight

391.42

Precautions

H302, H312, H332

References & Citations

[1]Tanaka M, et al. His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx. Peptides. 2009 Aug;30 (8) :1502-7.|[2]Kumrungsee T, et al. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells. Food Chem. 2014;152:218-24. |[3]Arispe N, et al. Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity. Biophys J. 2008 Nov 15;95 (10) :4879-89.