Livin/BIRC7 Protein, Human, Recombinant (His Tag)
Product Specifications
Background
BIRC7, a new member of inhibitor of the apoptosis protein family, is expressed in fetal tissues and most solid tumors in humans. BIRC7/livin expression is a novel prognostic marker in adult acute leukemia. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Livin/BIRC7 is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecular marker of malignancy.
Synonyms
KIAP Protein, Human; LIVIN Protein, Human; ML-IAP Protein, Human; MLIAP Protein, Human; RNF50 Protein, Human
Gene Name
Baculoviral IAP repeat containing 7
Expression System
E. coli
Tag
C-His
Endotoxin
Please contact us for more information.
Purity
> 85 % as determined by SDS-PAGE.
Activity
Measured by its ability to reverse the inhibition of DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP.The IC50 for this effect is typically 0.6-3.0 μM.
Form
Liquid
Buffer
Supplied as sterile 50 mM Tris, 200 mM NaCl, pH 8.0. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Molecular Weight
The recombinant human BIRC7 consists of 304 amino acids and predicts a molecular mass of 33.6 kDa. It migrates as an approximately 35 kDa band in SDS-PAGE under reducing conditions.
Storage Conditions
Liquid. It is shipped out with blue ice. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH50760E2.pdf
Symbol
BIRC7
Species
Human
Protein ID
AAH14475.1
Overview
A DNA sequence encoding the human BIRC7 (AAH14475.1) (Met1-Ser298) was expressed with a polyhistide tag at the C-terminus.
AA Sequence
Met1-Ser298
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/AAH14475.1
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