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Frizzled 6 Protein, Human, Recombinant (mFc Tag)

Product Specifications

Background

FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. The overexpression of FZD6 may play an important role in the development of Colorectal cancer (CRC) . FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. FZD6 plays crucial roles in human tumorigenesis.

Synonyms

FZ-6 Protein, Human; FZ6 Protein, Human; HFZ6 Protein, Human; NDNC10 Protein, Human

Gene Name

Frizzled class receptor 6

Expression System

HEK293 Cells

Tag

C-mFc

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

> 90 % as determined by SDS-PAGE.

Activity

At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.

Form

Lyophilized

Buffer

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Function

Cytokine Proteins, Growth Factor proteins, Receptor Proteins

Molecular Weight

The recombinant human FZD6 consists 369 amino acids and predicts a molecular mass of 42 kDa.

Storage Conditions

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Product Datasheet

http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH50334M4.pdf

Symbol

FZD6

Species

Human

Protein ID

NP_003497.2

Overview

A DNA sequence encoding the human FZD6 (NP_003497.2) (Met1-Val153) was expressed with the Fc region of mouse IgG1 at the C-terminus.

AA Sequence

Met1-Val153

Protein ID Link

https://www.ncbi.nlm.nih.gov/protein/NP_003497.2

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