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KIR2DL3 Protein, Human, Recombinant (ECD, hFc Tag)

Product Specifications

Background

Killer cell immunoglobulin-like receptor 2DL3, also known as CD158 antigen-like family member B2, KIR-23GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated transcript 2, p58 natural killer cell receptor clone CL-6, p58.2 MHC class-I-specific NK receptor, CD158b2, and KIR2DL3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. KIR2DL3 contains 2 Ig-like C2-type (immunoglobulin-like) domains. KIR2DL3 interacts with ARRB2. KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3, and HLA-Cw7) . KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

Synonyms

CD158b Protein, Human; CD158B2 Protein, Human; CU464054.1 Protein, Human; GL183 Protein, Human; KIR-023GB Protein, Human; KIR-K7b Protein, Human; KIR-K7c Protein, Human; KIR2DS5 Protein, Human; KIRCL23 Protein, Human; MGC129943 Protein, Human; NKAT Protein, Human; NKAT2 Protein, Human; NKAT2A Protein, Human; NKAT2B Protein, Human; p58 Protein, Human

Gene Name

Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3

Expression System

HEK293 Cells

Tag

C-hFc

Field of Research

ITIM/ITAM Immunoreceptors and Related Molecules

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

> 90 % as determined by SDS-PAGE.

Activity

At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.

Form

Lyophilized

Buffer

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Function

CD Molecule proteins, Biological Target proteins, Immune Checkpoint Proteins, Receptor Proteins

Molecular Weight

The recombinant human KIR2DL3 consists of 465 amino acids and predicts a molecular mass of 51.6 kDa.

Storage Conditions

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Product Datasheet

http://www.leading-biology.com/en/fastadmin/public/data/datasheet/S_Protein_datasheet/PH50229M4.pdf

Symbol

KIR2DL3

Species

Human

Protein ID

AAX23102.1

Overview

A DNA sequence encoding the human KIR2DL3 (AAX23102.1) (Met1-His245) was expressed with the Fc region of human IgG1 at the C-terminus.

AA Sequence

Met1-His245

Protein ID Link

https://www.ncbi.nlm.nih.gov/protein/AAX23102.1

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