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CEBPA Antibody - N-terminal region : HRP (P100908_P050-HRP)

Selected Variant

P100908_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

CCAAT/enhancer binding protein (C/EBP), alpha

Gene Aliases

CEBP, C/EBP-alpha

Gene ID

1050

Swiss Prot

P49715

Accession Number

NP_004355

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Guinea Pig, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human CEBPA

Target

CEBPA is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. It has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, CEBPA can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.

Partner Proteins

CEBPB; ZBTB16; RARA; HDAC1; BHLHE41; UBC; CEBPE; BATF2; BATF3; YY1AP1; ATF5; BATF; FOSL1; FOS; DBP; CEBPG; CEBPA; ATF4; ATF3; UBE3A; SKP2; RASGRF1; C1QBP; CDKN1A; SRA1; CDK4; PIAS1; Fbxw7; GRIN3A; RAB34; NAA16; POLR1E; MRTO4; AK5; MACF1; KAT5; AKAP9; SMC1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Sample Type

CEBPA is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Guinea Pig: 90%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

38kDa

References & Citations

Zhu, Q.S., et al., (2004) J. Biol. Chem. 279 (29), 29902-29910

Shipping Conditions

Wet Ice

Protein Length

358

NCBI Gene Symbol

CEBPA

NCBI GB Accession Number

CEBPA

Host or Source

Rabbit

Protein Name

CCAAT/enhancer-binding protein alpha

Nucleotide Accession Number

NM_004364

Peptide Sequence

GGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGG

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